Library
Co-occurring Conditions and Change in Diagnosis in Autism Spectrum Disorders
Pediatrics, January 2012
These findings suggest that the presence of co-occurring psychiatric and neurodevelopmental conditions are associated with a change in ASD diagnosis. Questions remain as to whether changes in diagnosis of an ASD are due to true etiologic differences or shifts in diagnostic determination.
Neuron Number and Size in Prefrontal Cortex of Children With Autism
Journal of the American Medical Association, November 2011
In this small preliminary study, brain overgrowth in males with autism involved an abnormal excess number of neurons in the prefrontal cortex.
An X-chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
Molecular Autism, November 4, 2011
The TBL1X gene may play a role in ASD risk.
Multivariate Searchlight Classification of Structural Magnetic Resonance Imaging in Children and Adolescents with Autism
Biological Psychiatry, September 5, 2011
Researchers using scanning technology discovered physical differences in the brains of older children with autism compared to those of kids without autism.
Increased de novo copy number variants in the offspring of older males
Translational Psychiatry, August 30, 2011
The offspring of older fathers have an increased risk of neurodevelopmental disorders, such as schizophrenia and autism.
Prevalence and Correlates of Autism in a State Psychiatric Hospital
National Center for Biotechnology Information, August 16, 2011
This study estimated the ASD prevalence in a psychiatric hospital and evaluated the Social Responsiveness Scale (SRS) combined with other information for differential diagnosis.
Adverse Effects of Vaccines: Evidence and Causality
Institute of Medicine, August 25, 2011
Overall, the committee concludes that few health problems are caused by or clearly associated with vaccines.
Detecting, Studying, and Treating Autism Early: The One-Year Well-Baby Check-Up Approach
Journal of Pediatrics, September 2011
The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.
Neocortical excitation/inhibition balance in information processing and social dysfunction
Nature, July 27, 2011
Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have been hypothesized to arise from elevations in the cellular balance of excitation and inhibition (E/I balance) within neural microcircuitry.
A novel functional brain imaging endophenotype of autism: the neural response to facial expression of emotion
Translational Psychiatry, July 12, 2011
The identification of a so-called 'biomarker' for a familial risk for autism could help scientists determine the causes behind the disorder.
The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism
Brain, July 6, 2011
Scientists at Carnegie Mellon University provide an explanation as to why autistic individuals' use of the wrong pronoun is more than simply a word choice problem. Researchers found that errors in choosing a self-referring pronoun reflect a disordered neural representation of the self, a function processed by at least two brain areas - one frontal and one posterior.
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
Achives of General Psychiatry, July 4, 2011
Susceptibility to ASD has moderate genetic heritability and a substantial shared twin environmental component.
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
Archives of General Psychiatry, July 2011
Susceptibility to ASD has moderate genetic heritability and a substantial shared twin environmental component.
Month of Conception and Risk of Autism
Epidemiology, July 2011
Higher risks for autism among those conceived in winter months suggest the presence of environmental causes of autism that vary by season.
Prenatal Vitamins, One-carbon Metabolism Gene Variants, and Risk for Autism
Epidemiology, July 2011
Periconceptional use of prenatal vitamins may reduce the risk of having children with autism, especially for genetically susceptible mothers and children. Replication and mechanistic investigations are warranted.
Prevalence of Autism Spectrum Disorders in a Total Population Sample
American Journal of Psychiatry, May 9, 2011
These findings suggest that rigorous screening and comprehensive population coverage are necessary to produce more accurate ASD prevalence estimates and underscore the need for better detection, assessment, and services.
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Nature, March 20, 2011
The shank3 gene is implicated in human autism.
Residential Proximity to Freeways and Autism in the CHARGE Study
Environmental Health Perspectives, December 2010
Living near a freeway was associated with autism. Examination of associations with measured air pollutants is needed.
Pediatrics, January 2012
These findings suggest that the presence of co-occurring psychiatric and neurodevelopmental conditions are associated with a change in ASD diagnosis. Questions remain as to whether changes in diagnosis of an ASD are due to true etiologic differences or shifts in diagnostic determination.
Neuron Number and Size in Prefrontal Cortex of Children With Autism
Journal of the American Medical Association, November 2011
In this small preliminary study, brain overgrowth in males with autism involved an abnormal excess number of neurons in the prefrontal cortex.
An X-chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
Molecular Autism, November 4, 2011
The TBL1X gene may play a role in ASD risk.
Multivariate Searchlight Classification of Structural Magnetic Resonance Imaging in Children and Adolescents with Autism
Biological Psychiatry, September 5, 2011
Researchers using scanning technology discovered physical differences in the brains of older children with autism compared to those of kids without autism.
Increased de novo copy number variants in the offspring of older males
Translational Psychiatry, August 30, 2011
The offspring of older fathers have an increased risk of neurodevelopmental disorders, such as schizophrenia and autism.
Prevalence and Correlates of Autism in a State Psychiatric Hospital
National Center for Biotechnology Information, August 16, 2011
This study estimated the ASD prevalence in a psychiatric hospital and evaluated the Social Responsiveness Scale (SRS) combined with other information for differential diagnosis.
Adverse Effects of Vaccines: Evidence and Causality
Institute of Medicine, August 25, 2011
Overall, the committee concludes that few health problems are caused by or clearly associated with vaccines.
Detecting, Studying, and Treating Autism Early: The One-Year Well-Baby Check-Up Approach
Journal of Pediatrics, September 2011
The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.
Neocortical excitation/inhibition balance in information processing and social dysfunction
Nature, July 27, 2011
Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have been hypothesized to arise from elevations in the cellular balance of excitation and inhibition (E/I balance) within neural microcircuitry.
A novel functional brain imaging endophenotype of autism: the neural response to facial expression of emotion
Translational Psychiatry, July 12, 2011
The identification of a so-called 'biomarker' for a familial risk for autism could help scientists determine the causes behind the disorder.
The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism
Brain, July 6, 2011
Scientists at Carnegie Mellon University provide an explanation as to why autistic individuals' use of the wrong pronoun is more than simply a word choice problem. Researchers found that errors in choosing a self-referring pronoun reflect a disordered neural representation of the self, a function processed by at least two brain areas - one frontal and one posterior.
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
Achives of General Psychiatry, July 4, 2011
Susceptibility to ASD has moderate genetic heritability and a substantial shared twin environmental component.
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
Archives of General Psychiatry, July 2011
Susceptibility to ASD has moderate genetic heritability and a substantial shared twin environmental component.
Month of Conception and Risk of Autism
Epidemiology, July 2011
Higher risks for autism among those conceived in winter months suggest the presence of environmental causes of autism that vary by season.
Prenatal Vitamins, One-carbon Metabolism Gene Variants, and Risk for Autism
Epidemiology, July 2011
Periconceptional use of prenatal vitamins may reduce the risk of having children with autism, especially for genetically susceptible mothers and children. Replication and mechanistic investigations are warranted.
Prevalence of Autism Spectrum Disorders in a Total Population Sample
American Journal of Psychiatry, May 9, 2011
These findings suggest that rigorous screening and comprehensive population coverage are necessary to produce more accurate ASD prevalence estimates and underscore the need for better detection, assessment, and services.
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Nature, March 20, 2011
The shank3 gene is implicated in human autism.
Residential Proximity to Freeways and Autism in the CHARGE Study
Environmental Health Perspectives, December 2010
Living near a freeway was associated with autism. Examination of associations with measured air pollutants is needed.